number of manuscripts being submitted (more than doubled in the last two years), and the restricted page budget, the selection process has necessarily become very strict with a rejection rate of over 50%. I encourage you to follow the suggestions of the referee and then submit to a more appropriate letters journal such as xxxxxx or xxxxxx Thank you for your consideration. In spite of the negative results in this case, I hope you will submit high-quality work from your laboratories to xxxxx in the future. With best regards, xxxxxx